ABSTRACT
Objective:To study the clinical and pathologic features of patients with lupus nephritis (LN) whose myeloperoxidase anti neutrophil cytoplasmic antibody (MPO ANCA) were positive. Methods:The clinical and pathological features were analyzed in 18 patients with LN whose MPO ANCA were positive. And the data of patients with different clinical outcomes were compared. Results:(1)The hematological abnormalities, hypertension and serositis in these patients were more common than general ones with LN. (2)Proteinuria and hematuria were common, the morbidities of gross hematuria and renal failure in these patients were higher than general ones with LN.(3)Various autoantibodies were positive in these patients.(4)Segmental necrosis crescentic nephritis accompanied by density of immunocomplex in glomeruli and vasculitis in intestitium were common.(5)The morbidity of ESRF and mortality of these patients were similar to general ones with LN. The morbidity of tubular atrophy in those with poor prognosis was significantly higher than those survived. Conclusion:The patients with LN whose MPO ANCA are positive have some difference from those with negative MPO ANCA, but positive MPO ANCA is not directly related to the prognosis. [